Wilms tumor 1 gene expression in acute myeloid leukemia: prognostic significance and usefulness in minimal residual disease monitoring—a case–control study

Abstract Background Minimal residual disease (MRD), which is characterized as leukemic cells at a level below morphologic detection, has been connected to the risk of relapse in acute myeloid leukemia. In 80–90% leukemia (AML) patients, Wilms tumor ( WT1 ) gene overexpressed mRNA level. our prospective study, total 55 patients were enrolled study. Group I involved 40 AML and group II 15 healthy controls. expression was quantified using quantitative real-time PCR on bone marrow samples from initial diagnosis day 28 after induction chemotherapy, compared controls II. Follow up for prognosis evaluation assessed. IBM SPSS software used capture analyses data. Results At diagnosis, mean transcript value substantially higher than observed control patient’s Bone marrow. There no statistically relevant relationship between onset expression. Patients with overexpression had shorter overall survival negative Conclusions 1 found be significantly cases, overall, results confirmed prognostic significance patients. Our findings support application MRD based overexpression.